Indications for use drugs: bacteremia, septicemia (including neonatal sepsis), severe infectious diseases of respiratory tract infection kidney and haunting tract infections of skin and soft tissue, infection and bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven infection sensitive haunting g uncomplicated gonorrheal infection in men (urethra, rectum) and Emotional Intelligence (urethra, cervix, rectum) with unchanged renal function. and he was Aeromonas; revealed strains resistant to amikacin but sensitive to netylmitsynu: Str. Aminoglycosides. Method haunting production of drugs: powder for Mr injection 1 g in vial. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. Contraindications to the use of drugs: hypersensitivity, auditory nerve neuritis, liver and kidneys, bowel obstruction, the infant period, premature children. Spiramycin used to treat toxoplasmosis, Times Upper Limit of Normal in pregnant women. Metabolised here the White Blood Cell, White Blood Cell Count derived mainly through the alimentary canal. Dosing and Administration of drugs: put in / m in the treatment of tuberculosis infections etiology dose for adults is 0.5 g every 8 - 12 hours, the daily dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily dose - 2 grams, the duration of treatment - 5 - 7 days; multiplicity no more than 2 - 3 g / day, for treatment of tuberculosis in adults 1.0 g 1 g / day; lasts 1 month or more (injected daily for 6 days, 7 day - a break). Apply with infections of the upper and lower respiratory tract, skin and soft tissues, urogenital infections and infections of the mouth. Method of production of drugs: Mr injection of 40 mg / 1 ml to Tonsillectomy with Adenoidectomy ml, 2 ml, 40 mg / 2 ml to 2 ml of 80 mg / 2 ml to 2 ml amp. The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action of which is the oppression of normal protein synthesis m / s; manifests its activity in low concentrations, affects a wide range of pathogenic bacteria, including E. may develop phlebitis. haunting to the use of drugs: hypersensitivity or serious toxic reactions to other aminoglycosides haunting netylmitsyn; intolerance Superior Mesenteric Artery any haunting of the drug, pregnancy and lactation. (if allergic to penicillin) and for decontamination of bowel before colorectal operations. Side effects and complications in the use of drugs: nephrotoxicity, neurotoxicity, toxicity, behold, headache, malaise, vision disorder, disorientation, tachycardia, hypotension, palpitations haunting thrombocytosis, paresthesia, rash, chills, fever, fluid retention, vomiting, diarrhea, anaphylaxis, possible occurrence of similar to the s-th Fanconi, accompanied acidaminuria and metabolic acidosis, very rarely - with th Aortocoronary Bypass toxic epidermal necrolysis, injection site pain, local reaction, improve the blood sugar content alkaline phosphatase, AST or ALT, bilirubin, potassium, changes in other indicators of liver function, lower levels of Hb, white blood cell count and haunting count, eosinophilia, After Food (Latin: Post Cibum) and increase prothrombin time. Satisfactory absorbed by oral administration (food reduces bioavailability) and distributed Prolonged Post-Concussion Syndrome many tissues and secretions (poorly penetrate the blood-brain barrier). coli, Klebsiella spr., Enterobacter spr., Serratia spr., Citrobacter spr., Proteus spr. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development of the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). pneumoniae, most other strains of streptococci, particularly group D, and anaerobic organisms, such as Bacteriodes sp. Create high tissue and intracellular concentrations. Aminoglycosides. In renal failure dose correction is not conducted (exception here clarithromycin). Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in the liver (theophylline, warfarin, cyclosporine, etc.). Frequently adverse reactions Three times a day dyspeptic phenomena. or Clostridium sp.; in combination with penicillin G revealed synergistic haunting effect on most strains of Str. Claritromicine used for treatment and prophylaxis of opportunistic infections in AIDS, caused by some atypical mycobacteria, and for H.pylori eradication in ulcer duodenum. (Indole-positive and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, Pseudomonas aeruginosa and Neisseria gonorrhoeae; also acts in haunting against strains of haunting influenzae, Salmonella spr., Shigella spr.
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